The ODF2 Polyclonal Antibody (CAB15630) is a critical tool for research involving ODF2, a protein essential for the formation and maintenance of the centriolar satellites involved in cell division and ciliogenesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards ODF2 in human samples, making it suitable for Western blot applications. By binding to the ODF2 protein, this antibody enables the detection and analysis of ODF2 in various cell types, allowing for in-depth studies in cell biology and development research.ODF2, also known as outer dense fiber 2, plays a crucial role in centriole organization and function, contributing to the accurate segregation of chromosomes during cell division.
Its involvement in cilia formation also underscores its importance in various cellular processes and developmental pathways. Research on ODF2 is integral to understanding the mechanisms underlying cell division and ciliogenesis, with implications for diseases related to ciliary dysfunction and defective cell division processes.Using the ODF2 Polyclonal Antibody (CAB15630) in your research will provide valuable insights into the functions of ODF2 in cellular processes, paving the way for potential therapeutic strategies targeting ODF2-related pathways in diseases such as ciliopathies and cancer.
Product Name:
ODF2 Rabbit Polyclonal Antibody
SKU:
CAB15630
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 630-829 of human ODF2 (NP_702911.1).
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.
Purification Method:
Affinity purification
Gene ID:
4957
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ODF2 Rabbit pAb (CAB15630) at dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
