The ODC1 Polyclonal Antibody (CAB1948) is a valuable tool for researchers studying ODC1, a key enzyme involved in the regulation of polyamine biosynthesis. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.ODC1, also known as ornithine decarboxylase, plays a critical role in cell growth and proliferation by catalyzing the decarboxylation of ornithine to form putrescine. Dysregulation of ODC1 has been linked to various diseases, including cancer and neurodegenerative disorders.
Therefore, understanding the expression and activity of ODC1 is essential for investigating potential therapeutic targets.By using the ODC1 Polyclonal Antibody, researchers can accurately detect and analyze ODC1 protein levels in various cell types, providing valuable insights into the role of polyamines in cellular processes. This antibody is an essential tool for studies in cancer research, neurobiology, and other fields where ODC1 is implicated.
Product Name:
ODC1 Rabbit Polyclonal Antibody
SKU:
CAB1948
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1).
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
4953
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ODC1 Rabbit pAb (CAB1948) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
