OASL Antibody (PACO14794)
- SKU:
- PACO14794
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
OASL Antibody (PACO14794)
The OASL Antibody (PAC014794) is a high-quality polyclonal antibody designed for research involving the OASL protein, a key player in the innate immune response against viral infections. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting and immunofluorescence.OASL, also known as 2'-5'-oligoadenylate synthetase-like protein, is a crucial component of the antiviral response pathway, specifically in the sensing of viral nucleic acids and activation of immune signaling. Studies have shown that OASL expression is upregulated in response to viral infections, pointing to its significance in host defense mechanisms against viruses.
Furthermore, OASL has been implicated in various diseases, including viral infections, autoimmune disorders, and inflammatory conditions. Understanding the role of OASL in these contexts can offer insights into potential therapeutic strategies for combating viral diseases and modulating immune responses.Overall, the OASL Antibody (PAC014794) provides researchers with a valuable tool for investigating the functions and mechanisms of OASL in the context of immune response and viral infections, ultimately contributing to advancements in the field of immunology and infectious disease research.
| Antibody Name: | OASL Antibody (PACO14794) |
| Antibody SKU: | PACO14794 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human OASL |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14794(OASL Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | OASL encodes an interferon-induced protein that is a member of the 2-5A synthetase family. 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, resulting in general RNA degradation and consequent inhibition of protein synthesis. 2-5As are produced by a well-conserved family of interferon-induced enzymes, the 2-5A synthetases or OASs |
| Synonyms: | 2'-5'-oligoadenylate synthetase-like |
| UniProt Protein Function: | OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1. |
| UniProt Protein Details: | Protein type:DNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm Molecular Function:2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; RNA binding; thyroid hormone receptor binding Biological Process: negative regulation of viral genome replication; response to virus |
| UniProt Code: | Q15646 |
| NCBI GenInfo Identifier: | 6226835 |
| NCBI Gene ID: | 8638 |
| NCBI Accession: | Q15646.2 |
| UniProt Secondary Accession: | Q15646,O75686, Q17R95, Q9Y6K6, Q9Y6K7, B2RAZ2, I1YDD2 |
| UniProt Related Accession: | Q15646 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | 2'-5'-oligoadenylate synthase-like protein |
| NCBI Synonym Full Names: | 2'-5'-oligoadenylate synthetase like |
| NCBI Official Symbol: | OASLÂ Â |
| NCBI Official Synonym Symbols: | OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASLÂ Â |
| NCBI Protein Information: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Protein Name: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Synonym Protein Names: | 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL |
| Protein Family: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Gene Name: | OASLÂ Â |
Related Products
OASL Antibody (PACO07450)
OASL Antibody (PACO14793)
OASL Polyclonal Antibody (CAB24529)
Human 2',5'-Oligoadenylate Synthetase Like Protein (OASL) ELISA Kit
