OASL Antibody (PACO14793)
- SKU:
- PACO14793
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
OASL Antibody (PACO14793)
The OASL Antibody (PAC014793) is a valuable research tool for studying OASL, an important innate immune response protein involved in antiviral defense. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in applications such as Western blotting. By binding to the OASL protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in virology and immunology research.
OASL is a key player in the cellular response to viral infections, acting as a potent antiviral factor that helps to limit viral replication and spread. Understanding the mechanisms by which OASL functions can provide insights into host defense strategies against viral pathogens, potentially leading to the development of novel antiviral therapies. Research into OASL is particularly relevant in the context of emerging viral diseases and the ongoing global efforts to combat infectious outbreaks.
| Antibody Name: | OASL Antibody (PACO14793) |
| Antibody SKU: | PACO14793 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human OASL |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: PACO14793(OASL Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO14793(OASL Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | OASL encodes an interferon-induced protein that is a member of the 2-5A synthetase family. 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, resulting in general RNA degradation and consequent inhibition of protein synthesis. 2-5As are produced by a well-conserved family of interferon-induced enzymes, the 2-5A synthetases or OASs |
| Synonyms: | 2'-5'-oligoadenylate synthetase-like |
| UniProt Protein Function: | OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1. |
| UniProt Protein Details: | Protein type:DNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm Molecular Function:2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; RNA binding; thyroid hormone receptor binding Biological Process: negative regulation of viral genome replication; response to virus |
| UniProt Code: | Q15646 |
| NCBI GenInfo Identifier: | 6226835 |
| NCBI Gene ID: | 8638 |
| NCBI Accession: | Q15646.2 |
| UniProt Secondary Accession: | Q15646,O75686, Q17R95, Q9Y6K6, Q9Y6K7, B2RAZ2, I1YDD2 |
| UniProt Related Accession: | Q15646 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | 2'-5'-oligoadenylate synthase-like protein |
| NCBI Synonym Full Names: | 2'-5'-oligoadenylate synthetase like |
| NCBI Official Symbol: | OASLÂ Â |
| NCBI Official Synonym Symbols: | OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASLÂ Â |
| NCBI Protein Information: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Protein Name: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Synonym Protein Names: | 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL |
| Protein Family: | 2'-5'-oligoadenylate synthase-like protein |
| UniProt Gene Name: | OASLÂ Â |
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