The Nyctalopin Polyclonal Antibody (CAB7830) is a valuable tool for researchers studying the Nyctalopin protein, which plays a crucial role in vision and visual signal transduction. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to Nyctalopin, the antibody allows for the detection and analysis of this important protein in various cell types, making it ideal for studies in ophthalmology and neuroscience research.Nyctalopin is a transmembrane protein found in the retina and is essential for proper visual function, particularly in dim light conditions.
Dysregulation of Nyctalopin has been linked to various retinal disorders, making it a promising target for therapeutic intervention. Understanding the role of Nyctalopin in visual signal processing is key to developing treatments for vision-related conditions such as night blindness and retinitis pigmentosa.Overall, the Nyctalopin Polyclonal Antibody is a valuable tool for researchers seeking to deepen their understanding of Nyctalopin's role in vision and potentially uncover new therapeutic strategies for retinal disorders.
Product Name:
NYX Rabbit Polyclonal Antibody
SKU:
CAB7830
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 282-481 of human NYX (NP_072089.1).
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB.
Purification Method:
Affinity purification
Gene ID:
60506
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using NYX Rabbit pAb (CAB7830) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
