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NXF5 Antibody (PACO28686)

SKU:
PACO28686
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • NXF5 Antibody PACO28686
  • NXF5 Antibody PACO28686
  • NXF5 Antibody PACO28686
€359

Description

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NXF5 Antibody (PACO28686)

The NXF5 Polyclonal Antibody (PACO28686) is a tool designed for researchers studying NXF5, a key protein involved in RNA processing and transportation within the cell. This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to NXF5, researchers can detect and analyze this protein in various cell types, making it an essential tool for studies in molecular biology and RNA metabolism.NXF5 is known to play a crucial role in mRNA export from the nucleus to the cytoplasm, a fundamental process in gene expression regulation.

Dysregulation of NXF5 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for research aimed at understanding disease mechanisms and developing therapeutic interventions. By investigating the function of NXF5, researchers can gain insights into the molecular pathways involved in these diseases and potentially identify new treatment strategies.

Antibody Name:NXF5 Antibody (PACO28686)
Antibody SKU:PACO28686
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Nuclear RNA export factor 5 protein (1-200AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Western blot
All lanes: NXF5 antibody at 4µg/ml + HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 43, 20, 36, 35 kDa
Observed band size: 46 kDa
.
Product ImageImmunofluorescent analysis of HepG2 cells using PACO28686 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human prostate cancer using PACO28686 at dilution of 1:100.
Background:Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
Synonyms:Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1), NXF5, TAPL1
UniProt Protein Function:NXF5: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5. Belongs to the NXF family. 6 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xq22Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; RNA bindingBiological Process: mRNA export from nucleus; multicellular organismal development; poly(A)+ mRNA export from nucleus; RNA transport
UniProt Protein Details:
NCBI Summary:This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]
UniProt Code:Q9H1B4
NCBI GenInfo Identifier:20978537
NCBI Gene ID:55998
NCBI Accession:Q9H1B4.1
UniProt Secondary Accession:Q9H1B4,Q9H1B0, Q9H1B1, Q9H1B2, Q9H1B3, A2RRM0, B1AV82 B1AV83, B1AV84, B1AV85
UniProt Related Accession:Q9H1B4
Molecular Weight:42,162 Da
NCBI Full Name:Nuclear RNA export factor 5
NCBI Synonym Full Names:nuclear RNA export factor 5
NCBI Official Symbol:NXF5  
NCBI Official Synonym Symbols:
NCBI Protein Information:nuclear RNA export factor 5
UniProt Protein Name:Nuclear RNA export factor 5
UniProt Synonym Protein Names:TAP-like protein 1; TAPL-1
Protein Family:Nuclear RNA export factor
UniProt Gene Name:NXF5  
UniProt Entry Name:NXF5_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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