The NXF3 Polyclonal Antibody (PACO10984) is a valuable tool for researchers studying NXF3, a nuclear RNA export factor involved in mRNA export from the nucleus to the cytoplasm. This antibody is raised in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications for the detection of NXF3 protein.NXF3 plays a crucial role in the regulation of gene expression by facilitating the transport of mRNA molecules out of the nucleus, allowing for translation to occur in the cytoplasm.
Dysregulation of NXF3 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a key focus of research in molecular biology and genetics. By using the NXF3 Polyclonal Antibody, researchers can explore the function and expression of NXF3 in different cell types and conditions, advancing our understanding of its role in cellular processes and disease development.
NXF3: May function as a tissue-specific nuclear mRNA export factor. Belongs to the NXF family.Chromosomal Location of Human Ortholog: Xq22Cellular Component: cytoplasm; nuclear RNA export factor complex; nucleoplasm; nucleusMolecular Function: mRNA binding; nucleotide binding; protein bindingBiological Process: mRNA export from nucleus; poly(A)+ mRNA export from nucleus
UniProt Protein Details:
NCBI Summary:
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
