NXF1 Rabbit Polyclonal Antibody (CAB5907)
- SKU:
- CAB5907
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | NXF1 Rabbit Polyclonal Antibody |
SKU: | CAB5907 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NXF1 (NP_006353.2). |
Sequence: | ILNE LKPE QVEQ LKLI MSKR YDGS QQAL DLKG LRSD PDLV AQNI DVVL NRRS CMAA TLRI IEEN IPEL LSLN LSNN RLYR LDDM SSIV QKAP NLKI LNLS G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TAP; MEX67; NXF1 |
Positive Sample: | HeLa,293T,Mouse spleen,Mouse lung,Mouse kidney,Rat spleen,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, Nucleus speckle, nucleoplasm. |
Calculated MW: | 70kDa |
Observed MW: | 70kDa |
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 10482 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |