The NUS1 Antibody (PAC010978) is a polyclonal antibody designed for research involving NUS1, a protein involved in lipid metabolism and transport. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blotting and immunofluorescence.NUS1 plays a crucial role in maintaining lipid homeostasis within cells, making it a key player in cellular metabolism and function. Dysregulation of NUS1 has been implicated in various diseases, including metabolic disorders and neurological conditions. Studying the function and expression of NUS1 using this antibody can provide valuable insights into these disease mechanisms and potentially lead to the development of novel therapeutic interventions.
With its high specificity and sensitivity, the NUS1 Antibody offers researchers a powerful tool for investigating the role of NUS1 in health and disease. Whether studying lipid metabolism, cellular signaling pathways, or disease pathology, this antibody can facilitate accurate detection and analysis of NUS1 in a variety of cell types and experimental conditions, making it an essential component of any research program focused on lipid biology and associated disorders.
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae);NUS1;C6orf68;MGC117249;MGC7199;MGC:7199;NgBR ;
UniProt Protein Function:
Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Ref.5 Ref.7Essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Ref.5 Ref.7Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2. Ref.6 Ref.7Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note: Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. Ref.6 Ref.7Miscellaneous: Although strongly related to UPP synthase family proteins, it has no lipid transferase activity.NUS1 seems to exist in two topological orientations, a minor glycosylated species with its C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its C-terminus directed towards the cytosol where it regulates cis-IPTase activity.Sequence similarities: Belongs to the UPP synthase family.Sequence caution: The sequence AAB72234.1 differs from that shown. Reason: Frameshift at several positions.
