UniProt Protein Function: | Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Ref.5 Ref.7Essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Ref.5 Ref.7Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2. Ref.6 Ref.7Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note: Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. Ref.6 Ref.7Miscellaneous: Although strongly related to UPP synthase family proteins, it has no lipid transferase activity.NUS1 seems to exist in two topological orientations, a minor glycosylated species with its C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its C-terminus directed towards the cytosol where it regulates cis-IPTase activity.Sequence similarities: Belongs to the UPP synthase family.Sequence caution: The sequence AAB72234.1 differs from that shown. Reason: Frameshift at several positions. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q96E22 |
NCBI GenInfo Identifier: | 20270243 |
NCBI Gene ID: | 116150 |
NCBI Accession: | NP_612468.1 |
UniProt Secondary Accession: | Q96E22,O00251, B2RWQ4 |
UniProt Related Accession: | Q96E22 |
Molecular Weight: | 33,224 Da |
NCBI Full Name: | nogo-B receptor |
NCBI Synonym Full Names: | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) |
NCBI Official Symbol: | NUS1Â Â |
NCBI Official Synonym Symbols: | NgBR; C6orf68; TANGO14; MGC:7199Â Â |
NCBI Protein Information: | nogo-B receptor; transport and golgi organization 14 homolog |
UniProt Protein Name: | Nogo-B receptor |
UniProt Synonym Protein Names: | Nuclear undecaprenyl pyrophosphate synthase 1 homolog |
Protein Family: | Dehydrodolichyl diphosphate synthase complex |
UniProt Gene Name: | NUS1Â Â |
UniProt Entry Name: | NGBR_HUMAN |