NUP37 Antibody (PACO39454)
- SKU:
- PACO39454
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NUP37 Antibody (PACO39454)
The NUP37 Polyclonal Antibody (PACO39454) is a valuable tool for researchers studying NUP37, a key component of the nuclear pore complex involved in nucleocytoplasmic transport. This antibody, generated in rabbits, demonstrates high specificity for human samples and is validated for use in various applications, including Western blotting. With the ability to bind to the NUP37 protein, this antibody enables precise detection and analysis in different cell types, making it an essential reagent for studies in cell biology and molecular biology.
NUP37 is essential for the proper functioning of the nuclear pore complex, which serves as the gateway for the transport of molecules between the nucleus and cytoplasm. Dysregulation of NUP37 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular processes. By studying the role of NUP37, researchers can gain insights into the mechanisms underlying these diseases and potentially uncover new therapeutic targets for intervention.
| Antibody Name: | NUP37 Antibody (PACO39454) |
| Antibody SKU: | PACO39454 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nucleoporin Nup37 protein (1-326AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. |
| Synonyms: | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37), NUP37 |
| UniProt Protein Function: | NUP37: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. |
| UniProt Protein Details: | Protein type:Nucleoporin Chromosomal Location of Human Ortholog: 12q23.2 Cellular Component: nucleoplasm; kinetochore; nuclear envelope; nucleus; cytosol Molecular Function:protein binding Biological Process: mitosis; mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; chromosome segregation; protein transport; cell division; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport |
| NCBI Summary: | Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP37 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8NFH4 |
| NCBI GenInfo Identifier: | 34222121 |
| NCBI Gene ID: | 79023 |
| NCBI Accession: | NP_076962.2 |
| UniProt Secondary Accession: | Q8NFH4,Q9H644, |
| UniProt Related Accession: | Q8NFH4 |
| Molecular Weight: | 36,708 Da |
| NCBI Full Name: | nucleoporin Nup37 |
| NCBI Synonym Full Names: | nucleoporin 37kDa |
| NCBI Official Symbol: | NUP37Â Â |
| NCBI Official Synonym Symbols: | p37Â Â |
| NCBI Protein Information: | nucleoporin Nup37 |
| UniProt Protein Name: | Nucleoporin Nup37 |
| UniProt Synonym Protein Names: | Nup107-160 subcomplex subunit Nup37 |
| Protein Family: | Nucleoporin |
| UniProt Gene Name: | NUP37Â Â |
| UniProt Entry Name: | NUP37_HUMAN |
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