NUP214 Rabbit Polyclonal Antibody (CAB8357)
- SKU:
- CAB8357
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | NUP214 Rabbit Polyclonal Antibody |
SKU: | CAB8357 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-1030 of human NUP214 (NP_005076.3). |
Sequence: | FLLE IKET TESL HGDI SSLK TTLL EGFA GVEE AREQ NERN RDSG YLHL LYKR PLDP KSEA QLQE IRRL HQYV KFAV QDVN DVLD LEWD QHLE QKKK QRHL LVPE RETL FNTL ANNR EIIN QQRK RLNH LVDS LQQL RLYK QTSL WSLS SAVP SQSS IHSF DSDL ESLC NALL KTTI ESHT KSLP KVPA KLSP MKQA QLRN FLAK RKTP PVRS TAPA SLSR SAFL SQRY YEDL DEVS STSS VSQS LESE DART SCKD DEAV VQAP RHAP VVRT PSIQ PSLL P |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | CAN; CAIN; IIAE9; NUP214 |
Positive Sample: | U-87MG,293T,Mouse brain,Mouse spleen,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nuclear pore complex. |
Calculated MW: | 214kDa |
Observed MW: | 251kDa/214kDa |
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 8021 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |