The Numb Polyclonal Antibody (CAB9352) is specifically designed for research involving Numb, a protein known for its role in cell development and differentiation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to the Numb protein, this antibody allows for precise detection and analysis in various cell types, making it an indispensable tool for studies in developmental biology and cancer research.Numb is a key player in the regulation of cell fate determination, particularly in processes like asymmetric cell division and cell fate specification.
Dysregulation of Numb has been implicated in various diseases, including cancer and neurodevelopmental disorders. Investigating the functions and mechanisms of Numb is essential for gaining insights into these pathologies and potentially identifying new therapeutic targets for intervention.Overall, the Numb Polyclonal Antibody (CAB9352) offers researchers a reliable and specific tool for studying the intricate roles of the Numb protein in cellular processes, paving the way for advancements in understanding developmental biology and disease pathology.
Product Name:
NUMB Rabbit Polyclonal Antibody
SKU:
CAB9352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 521-640 of human NUMB (NP_003735.3).
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NUMB Rabbit pAb (CAB9352) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
