The NUMA1 Polyclonal Antibody (CAB0527) is a valuable tool for researchers studying NUMA1, a protein involved in multiple cellular functions, including mitosis and spindle organization. This antibody, generated in rabbits, shows high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the NUMA1 protein, this antibody allows for the detection and analysis of NUMA1 expression in various cell types, making it ideal for studies in cell biology and cancer research.NUMA1 is a key player in spindle organization and chromosome segregation during cell division, making it essential for maintaining genomic stability.
Dysregulation of NUMA1 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the role of NUMA1 in cellular processes is crucial for developing targeted therapies for cancer and other diseases.Overall, the NUMA1 Polyclonal Antibody (CAB0527) offers researchers a reliable tool for studying NUMA1 function and its implications in cellular processes and disease development.
Product Name:
NUMA1 Rabbit Polyclonal Antibody
SKU:
CAB0527
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human NUMA1 (NP_006176.2).
Chromosome, Cytoplasm, Nucleus matrix, cytoskeleton, spindle pole.
Calculated MW:
238kDa
Observed MW:
238kDa
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4926
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NUMA1 Rabbit pAb (CAB0527) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
