The NUMA Rabit Monoclonal Antibody (CAB4416) is a cutting-edge research tool designed for scientists studying NUMA, an essential protein involved in mitosis and cell division regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used with human samples, making it an ideal choice for immunofluorescence, immunoprecipitation, and immunohistochemistry applications.NUMA, or Nuclear Mitotic Apparatus protein, plays a crucial role in organizing microtubules during mitosis and ensuring accurate chromosome segregation. Dysregulation of NUMA has been linked to various diseases, including cancer and developmental disorders.
By targeting NUMA with this monoclonal antibody, researchers can investigate its functions and interactions in different cell types, shedding light on its therapeutic potential in treating cancer and other related conditions.With its superior performance and reliability, the NUMA Rabbit Monoclonal Antibody (CAB4416) is a valuable tool for unraveling the complex mechanisms underlying cell division and exploring novel therapeutic strategies for combating diseases associated with NUMA dysfunction.
Product Name:
NUMA1 Rabbit Monoclonal Antibody
SKU:
CAB4416
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2000-2100 of human NUMA11 (Q14980).
Sequence:
TPES KKAT SCFP RPMT PRDR HEGR KQST TEAQ KKAA PAST KQAD RRQS MAFS ILNT PKKL GNSL LRRG ASKK ALSK ASPN TRSG TRRS PRIA TTTA SAAT A
Tested Applications:
WBIHC-PELISA
Recommended Dilution:
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:
NUMA; NMP-22; NUMA1
Positive Sample:
A-549,Mouse lung
Conjugate:
Unconjugated
Cellular Localization:
Chromosome, Cytoplasm, Nucleus matrix, cytoskeleton, spindle pole.
Calculated MW:
238kDa
Observed MW:
250kDa
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4926
Clone Number:
ARC1000
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NUMA11 Rabbit mAb (CAB4416) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
