NUDT15 Rabbit Polyclonal Antibody (CAB14141)
- SKU:
- CAB14141
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | NUDT15 Rabbit Polyclonal Antibody |
SKU: | CAB14141 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1). |
Sequence: | MTAS AQPR GRRP GVGV GVVV TSCK HPRC VLLG KRKG SVGA GSFQ LPGG HLEF GETW EECA QRET WEEA ALHL KNVH FASV VNSF IEKE NYHY VTIL MKGE VDVT HDSE PKNV EPEK NESW EWVP WEEL PPLD QLFW GLRC LKEQ GYDP FKED LNHL VGYK GNHL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 |
Synonyms: | MTH2; NUDT15D; NUDT15 |
Positive Sample: | rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 19kDa |
Observed MW: | 19kDa |
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
Purification Method: | Affinity purification |
Gene ID: | 55270 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |