The NUDT14 Polyclonal Antibody (PAC028658) is a crucial tool for researchers studying NUDT14, a protein involved in nucleotide metabolism and oxidative stress response. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By binding specifically to NUDT14, this antibody enables the detection and analysis of this protein in various cell types, facilitating research in fields such as biochemistry, molecular biology, and cancer biology.
NUDT14, also known as DIPP1, plays a key role in maintaining cellular homeostasis by regulating nucleotide pool levels and protecting cells from oxidative damage. Its involvement in these fundamental processes makes it a promising target for investigating diseases related to DNA repair, cell proliferation, and cell death. Understanding the function of NUDT14 may provide insights into developing novel therapeutic strategies for conditions such as cancer, neurodegenerative disorders, and metabolic diseases.
Antibody Name:
NUDT14 Antibody (PACO28658)
Antibody SKU:
PACO28658
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Uridine diphosphate glucose pyrophosphatase protein (1-222AA)
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
NUDT14: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose. Belongs to the Nudix hydrolase family.Protein type: Hydrolase; EC 3.6.1.45Chromosomal Location of Human Ortholog: 14q32.33Cellular Component: cytoplasmMolecular Function: protein binding; ADP-ribose diphosphatase activity; metal ion binding; UDP-sugar diphosphatase activityBiological Process: metabolic process
UniProt Protein Details:
NCBI Summary:
UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008]
