UniProt Protein Function: | NUDT14: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose. Belongs to the Nudix hydrolase family.Protein type: Hydrolase; EC 3.6.1.45Chromosomal Location of Human Ortholog: 14q32.33Cellular Component: cytoplasmMolecular Function: protein binding; ADP-ribose diphosphatase activity; metal ion binding; UDP-sugar diphosphatase activityBiological Process: metabolic process |
UniProt Protein Details: | |
NCBI Summary: | UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008] |
UniProt Code: | O95848 |
NCBI GenInfo Identifier: | 37594467 |
NCBI Gene ID: | 256281 |
NCBI Accession: | NP_803877.2 |
UniProt Secondary Accession: | O95848,Q86SJ8 |
UniProt Related Accession: | O95848 |
Molecular Weight: | 24,118 Da |
NCBI Full Name: | uridine diphosphate glucose pyrophosphatase |
NCBI Synonym Full Names: | nudix (nucleoside diphosphate linked moiety X)-type motif 14 |
NCBI Official Symbol: | NUDT14Â Â |
NCBI Official Synonym Symbols: | UGPP; UGPPase  |
NCBI Protein Information: | uridine diphosphate glucose pyrophosphatase; UDPG pyrophosphatase; UDP-sugar diphosphatase |
UniProt Protein Name: | Uridine diphosphate glucose pyrophosphatase |
UniProt Synonym Protein Names: | Nucleoside diphosphate-linked moiety X motif 14; Nudix motif 14 |
Protein Family: | Nudix hydrolase |
UniProt Gene Name: | NUDT14Â Â |
UniProt Entry Name: | NUD14_HUMAN |