| UniProt Protein Function: | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. |
| UniProt Protein Details: | |
| NCBI Summary: | NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96G61 |
| NCBI GenInfo Identifier: | 37221177 |
| NCBI Gene ID: | 55190 |
| NCBI Accession: | NP_060629.2 |
| UniProt Secondary Accession: | Q96G61,Q9NVN0 |
| UniProt Related Accession: | Q96G61 |
| Molecular Weight: | 18,559 Da |
| NCBI Full Name: | diphosphoinositol polyphosphate phosphohydrolase 3-beta |
| NCBI Synonym Full Names: | nudix hydrolase 11 |
| NCBI Official Symbol: | NUDT11Â Â |
| NCBI Official Synonym Symbols: | APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta  |
| NCBI Protein Information: | diphosphoinositol polyphosphate phosphohydrolase 3-beta |
| UniProt Protein Name: | Diphosphoinositol polyphosphate phosphohydrolase 3-beta |
| UniProt Synonym Protein Names: | Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; Diadenosine hexaphosphate hydrolase (AMP-forming) (EC:3.6.1.603 PublicationsManual assertion based on experiment iniRef.1"An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase."Hidaka K., Caffrey J.J., Hua L., Zhang T., Falck J.R., Nickel G.C., Carrel L., Barnes L.D., Shears S.B.J. Biol. Chem. 277:32730-32738(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY. |
| Protein Family: | Diphosphoinositol polyphosphate phosphohydrolase |
| UniProt Gene Name: | NUDT11Â Â |
| UniProt Entry Name: | |
