The NUDT11 Polyclonal Antibody (PACO38450) is a valuable tool for researchers studying NUDT11, a nucleoside diphosphate linked moiety X-type motif 11 enzyme involved in nucleotide metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the NUDT11 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and biochemistry.
NUDT11, also known as mitochondrial ADP-ribose pyrophosphatase, plays a crucial role in maintaining nucleotide balance within cells and regulating cellular signaling pathways involved in metabolism and DNA repair. Its function in nucleotide metabolism makes it an attractive target for research into diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Understanding the activity of NUDT11 is essential for developing targeted therapies that manipulate nucleotide metabolism for therapeutic purposes.
Western blot. All lanes: NUDT11 antibody at 2µg/ml + U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 19 kDa. Observed band size: 19 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO38450 at dilution of 1:100.
Background:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
UniProt Protein Details:
NCBI Summary:
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
