MTH1 Rabbit Polyclonal Antibody (CAB5474)
- SKU:
- CAB5474
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MTH1 Rabbit Polyclonal Antibody |
SKU: | CAB5474 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human MTH1 (NP_945192.1). |
Sequence: | MSGI SPQQ MGEP EGSW SGKN PGTM GASR LYTL VLVL QPQR VLLG MKKR GFGA GRWN GFGG KVQE GETI EDGA RREL QEES GLTV DALH KVGQ IVFE FVGE PELM DVHV FCTD SIQG TPVE SDEM RPCW FQLD QIPF KDMW PDDS YWFP LLLQ KKKF HGYF KFQG QDTI LDYT LREV DTV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MTH1 |
Positive Sample: | SW480,K-562,22Rv1,THP-1,HepG2,SKOV3,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion matrix, Nucleus. |
Calculated MW: | 18kDa |
Observed MW: | 18kDa |
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Purification Method: | Affinity purification |
Gene ID: | 4521 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |