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NUDT1 Monoclonal Antibody [PAT3B3AT] (CPAB0209)

SKU:
CPAB0209
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT3B3AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

NUDT1 Monoclonal Antibody [PAT3B3AT] (CPAB0209)

The NUDT1 Polyclonal Antibody (CPAB0209) is a valuable tool for researchers studying NUDT1, a protein involved in DNA repair and oxidative stress response. This antibody, raised in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to the NUDT1 protein, it allows for the detection and analysis of NUDT1 in a variety of cell types, making it ideal for studies in molecular biology and cancer research.NUDT1, also known as nudix hydrolase 1, plays a crucial role in maintaining genomic stability by repairing DNA damage caused by reactive oxygen species.

Its involvement in DNA repair pathways and antioxidant defense mechanisms makes it an attractive target for investigating diseases such as cancer, neurodegenerative disorders, and aging-related conditions. Understanding the function of NUDT1 is essential for developing therapeutic strategies aimed at enhancing DNA repair efficiency and reducing oxidative stress-induced damage.

Product Name:NUDT1 Antibody
Product Sku:CPAB0209
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NUDT1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NUDT1 amino acids 1-156 purified from Ecoli.
Clone:PAT3B3AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:NUDT1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. NUDT1 is found mostly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Moreover, NUDT1 is expressed at much higher levels in proliferating cells than in resting cells. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations which may result in carcinogenesis or neurodegeneration.
Synonyms:7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, NUDT1, MTH1, Nudix Type Motif 1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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