The NUB1 Polyclonal Antibody (CAB18665) is a valuable tool for research involving NUB1, a protein involved in the regulation of protein degradation and cellular stress response. The antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the NUB1 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for studies in cell biology and molecular biology.NUB1 is known for its role in mediating the degradation of misfolded proteins and promoting cell survival under stressful conditions.
Its involvement in protein quality control mechanisms and stress response pathways makes it a key player in cellular homeostasis and disease progression. Research on NUB1 is essential for understanding its function in neurodegenerative diseases, cancer, and other disorders where protein stability and cellular stress play a critical role.Overall, the NUB1 Polyclonal Antibody is a reliable tool for investigating the function and regulation of NUB1 in various biological processes, providing valuable insights into the mechanisms underlying protein degradation and cellular stress responses.
Product Name:
NUB1 Rabbit Polyclonal Antibody
SKU:
CAB18665
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFT140 (NP_001350458.1).
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NUB1 Rabbit pAb (CAB18665) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 300s.
