The NTSR2 Polyclonal Antibody (PAC018299) is a valuable tool for researchers studying NTSR2, a G-protein coupled receptor involved in the regulation of physiological processes such as pain perception and cardiovascular function. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NTSR2 protein, this antibody enables the detection and analysis of NTSR2 in various cell types, making it ideal for studies in neuroscience, pain research, and cardiovascular biology.
NTSR2 is known to play a crucial role in mediating the effects of neurotensin, a neuropeptide implicated in pain modulation and cardiovascular regulation. Understanding the function of NTSR2 is essential for elucidating its role in various physiological processes and may have implications for the development of therapeutics targeting pain disorders and cardiovascular diseases. The NTSR2 Polyclonal Antibody is a valuable tool for researchers seeking to further explore the function of NTSR2 and its potential as a therapeutic target.
Antibody Name:
NTSR2 Antibody (PACO18299)
Antibody SKU:
PACO18299
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human NTSR2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO18299(NTSR2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
Background:
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
Synonyms:
neurotensin receptor 2
UniProt Protein Function:
NTSR2: neurotensin receptor 2
UniProt Protein Details:
Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: regulation of membrane potential; cell surface receptor linked signal transduction; neuropeptide signaling pathway; sensory perception; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
NCBI Summary:
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
