The NTRK3 Polyclonal Antibody (CAB5842) is a vital tool for researchers studying the NTRK3 protein, also known as the Neurotrophic Tyrosine Kinase Receptor Type 3. This protein is involved in neuronal development and function, playing a crucial role in the growth, survival, and differentiation of neurons.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the NTRK3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in neuroscience and neurobiology.The NTRK3 protein is known to be a key player in neural development and has been implicated in various neurological disorders, including schizophrenia, bipolar disorder, and neurodevelopmental disorders.
Understanding the function and regulation of NTRK3 is essential for developing therapies that target this protein and potentially treating these debilitating conditions.Overall, the NTRK3 Polyclonal Antibody (CAB5842) is a valuable resource for researchers looking to unravel the complexities of neuronal signaling and development, offering insight into potential targets for therapeutic intervention in neurological disorders.
Product Name:
NTRK3 Rabbit Polyclonal Antibody
SKU:
CAB5842
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1).
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TrKC antibody (CAB5842) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
