NTRK3 Rabbit Polyclonal Antibody (CAB5842)
- SKU:
- CAB5842
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | NTRK3 Rabbit Polyclonal Antibody |
SKU: | CAB5842 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1). |
Sequence: | KTEI NCRR PDDG NLFP LLEG QDSG NSNG NASI NITD ISRN ITSI HIEN WRSL HTLN AVDM ELYT GLQK LTIK NSGL RSIQ PRAF AKNP HLRY INLS SNRL TTLS WQLF QTLS LREL QLEQ NFFN CSCD IRWM QLWQ EQGE AKLN SQNL YCIN ADGS QLPL FRMN ISQC DLPE ISVS HVNL TVRE GDNA VITC NGSG SPLP DVDW IVTG LQSI NTHQ TNLN WTNV HAIN LTLV NVTS EDNG FTLT CIAE NVVG MSNA SVAL T |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | TRKC; GP145-TrkC; gp145(trkC); TrKC |
Positive Sample: | A-549,BT-474,HepG2,Mouse brain,MCF7,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 94kDa |
Observed MW: | 110-115kDa |
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4916 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |