The NTRK3 Polyclonal Antibody (CAB14033) is a valuable tool for researchers studying the NTRK3 gene, which encodes for the neurotrophic tyrosine kinase receptor type 3. This receptor plays a key role in neuronal development and function, making it of particular interest in neurobiology and neuroscience research.The antibody, generated in rabbits, is highly specific for detecting NTRK3 protein expression in human samples. It has been validated for use in Western blot applications, allowing researchers to accurately analyze and quantify NTRK3 levels in various cell types and tissues.
Understanding the function of NTRK3 is essential for unraveling its role in neurological diseases, such as Alzheimer's, Parkinson's, and various psychiatric disorders. By studying the activity of NTRK3, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.Overall, the NTRK3 Polyclonal Antibody (CAB14033) is a valuable tool for investigating the role of NTRK3 in neuronal development and neurological disorders, paving the way for advancements in neuroscience and potential clinical applications.
Product Name:
NTRK3 Rabbit Polyclonal Antibody
SKU:
CAB14033
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1).
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TrKC antibody (CAB14033) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
