The NTRK2 Polyclonal Antibody (CAB2099) is a valuable tool for researchers studying NTRK2, a neurotrophic tyrosine kinase receptor involved in the regulation of neuronal development and function. This antibody, produced in rabbits, has high reactivity with human samples and is suitable for use in Western blotting applications.NTRK2, also known as TrkB, is a key player in neurotrophic signaling pathways and has been implicated in various neurological and psychiatric disorders. By targeting the NTRK2 protein, this antibody allows for the detection and analysis of NTRK2 expression in different cell types, making it an ideal choice for studies in neuroscience and neurobiology.
Understanding the role of NTRK2 in neuronal growth, survival, and plasticity is essential for advancing our knowledge of neurological disorders such as Alzheimer's disease, depression, and epilepsy. The NTRK2 Polyclonal Antibody is a valuable tool for researchers working towards the development of novel therapeutics targeting the NTRK2 signaling pathway.
Product Name:
TrkB Rabbit Polyclonal Antibody
SKU:
CAB2099
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-430 of human TrkB (NP_001018074.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
140kDa
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkB Rabbit pAb (CAB2099) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
