The NTRK2 Polyclonal Antibody (CAB12325) is a vital tool for researchers studying the NTRK2 protein, a member of the neurotrophic tyrosine kinase receptor family involved in neuronal development and function. This antibody, generated in rabbits, is highly specific to NTRK2 and has been validated for use in various applications, including Western blot and immunohistochemistry.NTRK2, also known as TrkB, plays a crucial role in promoting neuronal survival and differentiation, as well as synaptic transmission in the brain. Dysfunction of NTRK2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression.
By targeting NTRK2, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop novel therapeutic strategies.This polyclonal antibody offers researchers a reliable tool for studying NTRK2 expression and localization in different cell types and tissues, making it ideal for neuroscience research and drug discovery efforts targeting the NTRK2 signaling pathway. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of neurobiology and developing targeted therapies for neurological diseases.
Product Name:
TrkB Rabbit Polyclonal Antibody
SKU:
CAB12325
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 41-433 of human TrkB (NP_001007098.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
105kDa
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkB Rabbit pAb (CAB12325) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
