The NTRK2 Polyclonal Antibody (CAB12011) is a vital tool for researchers studying the NTRK2 protein, a member of the neurotrophic tyrosine kinase receptor family that plays a key role in neuronal development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications, allowing for precise detection and analysis of NTRK2 protein levels in various cell types.NTRK2, also known as TrkB, is essential for the growth, survival, and synaptic plasticity of neurons, making it a crucial target for research in neuroscience and neurodegenerative diseases.
Dysregulation of NTRK2 signaling has been implicated in conditions such as Alzheimer's disease, Parkinson's disease, and depression, highlighting the importance of understanding its function and regulation.By utilizing the NTRK2 Polyclonal Antibody, researchers can further investigate the molecular mechanisms underlying NTRK2 signaling pathways and explore potential therapeutic targets for neurological disorders. This antibody serves as a valuable tool for advancing our knowledge of neurobiology and developing innovative treatments for neurological conditions.
Product Name:
TrkB Rabbit Polyclonal Antibody
SKU:
CAB12011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 41-433 of human TrkB (NP_001007098.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
110kDa
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkB Rabbit pAb (CAB12011) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
