The NTRK1 Polyclonal Antibody (CAB15618) is a valuable tool for researchers studying the NTRK1 gene, which encodes for the TrkA protein involved in nerve growth and development. This antibody, produced in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.TrkA is a receptor tyrosine kinase that plays a crucial role in the development and function of the nervous system. Dysregulation of NTRK1 has been implicated in a variety of neurological disorders, including cancer, Alzheimer's disease, and pain syndromes.
By targeting the TrkA protein, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.Whether studying neurobiology, oncology, or pain research, the NTRK1 Polyclonal Antibody is an essential tool for detecting and analyzing NTRK1 expression in various cell types. Its high specificity and sensitivity make it a reliable choice for researchers seeking to unravel the complexities of the NTRK1 signaling pathway and its implications for human health.
Product Name:
TrkA Rabbit Polyclonal Antibody
SKU:
CAB15618
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-796 of human TrkA (NP_002520.2).
Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein.
Calculated MW:
87kDa
Observed MW:
140kDa
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Purification Method:
Affinity purification
Gene ID:
4914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkA Rabbit pAb (CAB15618) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
