The NTHL1 Polyclonal Antibody (CAB6820) is specifically designed for research involving NTHL1, a key enzyme involved in base excision repair and maintenance of genomic stability. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the NTHL1 protein, researchers can accurately detect and analyze NTHL1 expression in various cell types.NTHL1 is crucial for repairing oxidative DNA damage and preventing mutations that can lead to cancer and other genetic disorders. Studies have shown that mutations in the NTHL1 gene are associated with an increased risk of developing certain cancers, making it a promising target for cancer research.
Understanding the role of NTHL1 in DNA repair processes is essential for developing novel therapies and diagnostic tools for cancer and other genetic diseases. Overall, the NTHL1 Polyclonal Antibody (CAB6820) is a valuable tool for researchers studying DNA repair mechanisms, genomic stability, and disease pathogenesis. Its high specificity and sensitivity make it a reliable choice for immunology, oncology, and genetic research projects.
Product Name:
NTHL1 Rabbit Polyclonal Antibody
SKU:
CAB6820
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NTHL1 (NP_002519.1).
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.
Purification Method:
Affinity purification
Gene ID:
4913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NTHL1 antibody (CAB6820) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
