The NTAN1 Polyclonal Antibody (CAB15562) is a valuable tool for researchers studying NTAN1, a protein involved in the N-terminal acetylation pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting. By targeting the NTAN1 protein, this antibody allows for the detection and analysis of NTAN1 levels in different cell types, making it ideal for studies in biochemistry and cellular biology.NTAN1 is a key player in the N-terminal acetylation process, which is essential for the regulation of protein stability, localization, and function.
Dysregulation of this pathway has been linked to various diseases, including neurodegenerative disorders and cancer. By investigating the role of NTAN1, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the NTAN1 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complexities of the N-terminal acetylation pathway and its implications in health and disease. Its specificity and sensitivity make it a reliable option for studying NTAN1 expression and function in a variety of experimental settings.
Product Name:
NTAN1 Rabbit Polyclonal Antibody
SKU:
CAB15562
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human NTAN1 (NP_775745.1).
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Purification Method:
Affinity purification
Gene ID:
123803
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NTAN1 Rabbit pAb (CAB15562) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
