The NT5C1B Polyclonal Antibody (PAC02296) is a valuable tool for research involving NT5C1B, a cytosolic 5'-nucleotidase enzyme that plays a crucial role in purine nucleotide metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blotting.NT5C1B is involved in the conversion of nucleoside monophosphates to nucleosides, a key step in nucleotide catabolism. Dysregulation of NT5C1B has been linked to various diseases, including cancer, immune disorders, and neurological conditions.
By targeting NT5C1B, researchers can gain insights into the molecular mechanisms underlying these diseases and explore potential therapeutic strategies.With its high specificity and sensitivity, the NT5C1B Polyclonal Antibody is an essential tool for studying NT5C1B expression and function in different cell types and tissues. Its versatility makes it an ideal choice for researchers in fields such as biochemistry, cell biology, and drug discovery. Unlock the potential of NT5C1B research with this reliable antibody.
Antibody Name:
NT5C1B Antibody (PACO22296)
Antibody SKU:
PACO22296
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human NT5C1B.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunofluorescence analysis of A549 cells, using NT5C1B antibody.
Background:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels By similarity.
NT5C1B: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. Belongs to the 5'-nucleotidase type 3 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Nucleotide Metabolism - purine; HydrolaseChromosomal Location of Human Ortholog: 2p24.2Cellular Component: cytosol; nucleusMolecular Function: 5'-nucleotidase activity; magnesium ion binding; nucleotide bindingBiological Process: dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; purine nucleotide catabolic process; purine base metabolic process
UniProt Protein Details:
NCBI Summary:
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]
