The NT5C1B Polyclonal Antibody (PACO06027) is a valuable tool for researchers studying NT5C1B, an enzyme involved in nucleotide metabolism and cell signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in various research applications such as Western blot and immunohistochemistry.NT5C1B, also known as cytosolic 5'-nucleotidase 1B, plays a crucial role in maintaining cellular nucleotide balance and regulating purine metabolism. Dysregulation of NT5C1B has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions.
By targeting NT5C1B, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets.Overall, the NT5C1B Polyclonal Antibody (PACO06027) is a reliable tool for investigating the function and regulation of NT5C1B in physiological and pathological conditions. Its high specificity and versatility make it an essential resource for scientists conducting research in the fields of biochemistry, cell biology, and disease pathology.
Antibody Name:
NT5C1B Antibody (PACO06027)
Antibody SKU:
PACO06027
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human AIRP.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
NT5C1B: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. Belongs to the 5'-nucleotidase type 3 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Nucleotide Metabolism - purine; HydrolaseChromosomal Location of Human Ortholog: 2p24.2Cellular Component: cytosol; nucleusMolecular Function: 5'-nucleotidase activity; magnesium ion binding; nucleotide bindingBiological Process: dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; purine nucleotide catabolic process; purine base metabolic process
UniProt Protein Details:
NCBI Summary:
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]
