The NT5C1A Polyclonal Antibody (PACO6024) is a valuable tool for researchers studying NT5C1A, a key enzyme involved in nucleotide metabolism and DNA repair. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the NT5C1A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.
NT5C1A, also known as cytosolic 5'-nucleotidase 1A, plays a crucial role in maintaining nucleotide balance and DNA integrity within cells. Dysregulation of NT5C1A has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. Investigating the function of NT5C1A is critical for uncovering its role in disease development and identifying potential treatment strategies aimed at restoring cellular balance.
Antibody Name:
NT5C1A Antibody (PACO06024)
Antibody SKU:
PACO06024
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the Internal region of human NT5C1A.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
NT5C1A: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Belongs to the 5'-nucleotidase type 3 family.Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 1p34.3-p33Cellular Component: cytosolMolecular Function: 5'-nucleotidase activity; magnesium ion binding; nucleotide bindingBiological Process: adenosine metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; nucleoside metabolic process; purine base metabolic process; purine nucleoside monophosphate catabolic process; purine nucleotide catabolic process; pyrimidine base metabolic process; pyrimidine nucleoside catabolic process
UniProt Protein Details:
NCBI Summary:
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]
