The NSUN2 Polyclonal Antibody (CAB3443) is a specialized research tool designed for the study of NSUN2, an RNA methyltransferase enzyme involved in the regulation of gene expression. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding specifically to the NSUN2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an invaluable tool for investigations in molecular biology and cancer research.NSUN2 is a crucial enzyme in the process of RNA modification, playing a key role in regulating RNA stability and protein translation. Dysregulation of NSUN2 has been linked to cancer progression and other diseases, making it a target of interest for therapeutic development.
By studying the function and activity of NSUN2, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new treatment strategies.The NSUN2 Polyclonal Antibody is an essential resource for scientists seeking to deepen their understanding of RNA modification and its implications in human health and disease. Its versatility and specificity make it ideal for a wide range of research applications, from basic science investigations to drug discovery efforts aimed at targeting NSUN2-related pathways.
Product Name:
NSUN2 Rabbit Polyclonal Antibody
SKU:
CAB3443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 617-708 of human NSUN2 (NP_060225.4).
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
54888
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NSUN2 Rabbit pAb (CAB3443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
