The NS1 Polyclonal Antibody (PAC061846) is a valuable tool for research involving the NS1 protein, a key player in viral infection and immune evasion. This antibody, generated in rabbits, exhibits high reactivity with NS1 in human samples and is validated for use in Western blot applications. It specifically binds to the NS1 protein, facilitating its detection and analysis in various experimental settings.NS1 is a non-structural protein found in certain viruses, including influenza, dengue, and Zika viruses, where it plays a crucial role in evading the host immune response.
Understanding the function and regulation of NS1 is essential for unraveling the mechanisms of viral pathogenesis and developing effective antiviral strategies. The NS1 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of NS1 in viral infections and immune modulation, making it a valuable asset in virology and immunology research.
Antibody Name:
NS1 Antibody (PACO61846)
Antibody SKU:
PACO61846
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human parvovirus B19
Immunogen:
Recombinant Human parvovirus B19 Non-capsid protein NS-1 protein (1-255AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: NS1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Background:
Seems necessary for viral DNA replication.
Synonyms:
Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1), NS1
UniProt Protein Function:
Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Upregulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release.
