The NS Antibody (PAC061854) offered by AssayGenie is a highly specific polyclonal antibody designed for research involving the NS protein. The antibody, generated in rabbits, has shown high reactivity with human samples and is validated for use in Western blot applications. It binds specifically to the NS protein, enabling accurate detection and analysis in various cell types, making it an ideal tool for studies in virology and infectious disease research.The NS protein, also known as non-structural protein, plays a crucial role in the replication and lifecycle of certain viruses.
Understanding the function and activity of the NS protein is essential for studying viral pathogenesis, host-virus interactions, and the development of antiviral therapies. The NS Antibody from AssayGenie provides researchers with a reliable and effective tool for investigating the role of the NS protein in viral infections and related diseases.
Antibody Name:
NS Antibody (PACO61854)
Antibody SKU:
PACO61854
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Influenza A virus
Immunogen:
Recombinant Influenza A virus Non-structural protein 1 protein (1-237AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: NS antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.
Background:
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA.
Synonyms:
Non-structural protein 1 (NS1) (NS1A), NS
UniProt Protein Function:
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA.
