The NS Monoclonal Antibody (PAC060937) is a vital tool for researchers studying NS, a key protein involved in viral replication and pathogenesis. This antibody, produced in mice, exhibits high specificity and sensitivity towards NS in a range of species, including humans. It has been verified for use in Western blotting and immunofluorescence assays, allowing for the accurate detection and localization of NS in various experimental setups.NS, an essential component of certain viruses, plays a pivotal role in viral replication and evasion of host immune responses.
Understanding the function and interactions of NS is critical for developing antiviral strategies and vaccines, particularly in the context of emerging and re-emerging viral diseases. The NS Monoclonal Antibody is a valuable tool for investigating the mechanisms of viral infection and identifying potential targets for therapeutic intervention.
Antibody Name:
NS Antibody (PACO60937)
Antibody SKU:
PACO60937
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Influenza A virus
Immunogen:
Recombinant Influenza A virus Non-structural protein 1 protein (152-237AA)
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
Synonyms:
Non-structural protein 1 (NS1) (NS1A), NS
UniProt Protein Function:
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
