NRXN3 Antibody (PACO45332)
- SKU:
- PACO45332
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NRXN3 Antibody (PACO45332)
The NRXN3 Polyclonal Antibody (PAC045332) is an essential tool for researchers studying NRXN3, a cell adhesion molecule vital for synaptic function in the brain. This antibody is generated in rabbits and shows high specificity for human samples, making it ideal for a range of experimental techniques including Western blotting. By targeting NRXN3, this antibody enables the visualization and analysis of NRXN3 protein expression in various cell types, providing valuable insights for neurological research.
NRXN3 is a key player in synaptic communication, serving as a critical mediator for neurotransmitter release and synaptic plasticity. Dysfunction in NRXN3 has been implicated in various neurodevelopmental and neuropsychiatric disorders, making it a promising target for therapeutic interventions. By understanding the role of NRXN3 in synaptic function, researchers can uncover new strategies for treating conditions such as autism spectrum disorders, schizophrenia, and epilepsy.
| Antibody Name: | NRXN3 Antibody (PACO45332) |
| Antibody SKU: | PACO45332 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Neurexin-3 protein (1584-1643AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: NRXN3 antibody at 2.03µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 181, 118, 154, 70, 48, 44, 51 kDa. Observed band size: 70 kDa.. |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO45332 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO45332 at dilution of 1:100. |
| Background: | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. |
| Synonyms: | Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha), NRXN3, C14orf60 KIAA0743 |
| UniProt Protein Function: | NRXN3: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 7 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 14q31 Cellular Component: integral to plasma membrane; integral to membrane Molecular Function:metal ion binding; calcium channel regulator activity; receptor activity; cell adhesion molecule binding Biological Process: positive regulation of synaptogenesis; axon guidance; synaptic transmission; synaptogenesis; neurotransmitter secretion; adult behavior; neuron adhesion; learning; angiogenesis; social behavior |
| NCBI Summary: | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9Y4C0 |
| NCBI GenInfo Identifier: | 21070969 |
| NCBI Gene ID: | 9369 |
| NCBI Accession: | NP_004787 |
| UniProt Related Accession: | Q9HDB5,Q9Y4C0 |
| Molecular Weight: | 180 |
| NCBI Full Name: | neurexin 3 isoform 1 |
| NCBI Synonym Full Names: | neurexin 3 |
| NCBI Official Symbol: | NRXN3Â Â |
| NCBI Official Synonym Symbols: | C14orf60Â Â |
| NCBI Protein Information: | neurexin 3 |
| UniProt Protein Name: | Neurexin-3 |
| UniProt Synonym Protein Names: | Neurexin III-alpha; Neurexin-3-alpha |
| Protein Family: | Neurexin |
| UniProt Gene Name: | NRXN3Â Â |
| UniProt Entry Name: | NRX3A_HUMAN |
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