NRXN3 Antibody (PACO41366)
- SKU:
- PACO41366
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NRXN3 Antibody (PACO41366)
The NRXN3 Polyclonal Antibody (PAC041366) is a valuable tool for research involving NRXN3, a member of the neurexin family known to play a key role in synaptic function and neurological disorders. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.NRXN3 is a synaptic adhesion molecule that interacts with various proteins to regulate neurotransmission and synaptic plasticity. Dysregulation of NRXN3 has been associated with neurological disorders such as schizophrenia, autism, and addiction, making it an important target for research in neuroscience and mental health.
The NRXN3 antibody enables the detection and analysis of NRXN3 protein levels in different cell types, aiding in the investigation of its role in synaptic communication and the pathology of related disorders.Understanding the function and regulation of NRXN3 is essential for advancing our knowledge of neurological diseases and developing targeted therapeutic interventions. The NRXN3 Polyclonal Antibody is a reliable tool for researchers seeking to uncover the molecular mechanisms underlying synaptic dysfunction and mental health conditions.
| Antibody Name: | NRXN3 Antibody (PACO41366) |
| Antibody SKU: | PACO41366 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Neurexin-3-β protein (201-432AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: NRXN3 antibody at 2µg/ml + Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 70, 48, 44, 51 kDa. Observed band size: 70 kDa. |
| Background: | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. |
| Synonyms: | Neurexin-3-β (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)], NRXN3, KIAA0743 |
| UniProt Protein Function: | NRXN3B: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. {ECO:0000250}. Belongs to the neurexin family. {ECO:0000305}. The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3. Weakly interacts with CBLN1 and CBLN2. Very weak binding, if any, with CBLN4. {ECO:0000250}. 7 isoforms of the human protein are produced by alternative promoter |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q24.3-q31.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:cell adhesion molecule binding; receptor activity Biological Process: adult behavior; axon guidance; learning; neuron adhesion; social behavior |
| NCBI Summary: | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9HDB5 |
| NCBI GenInfo Identifier: | 218512141 |
| NCBI Gene ID: | 9369 |
| NCBI Accession: | Q9HDB5.4 |
| UniProt Secondary Accession: | Q9HDB5,Q6NUR0, Q8IUD8, A5PKW8, A8MPU5, B3KPM7, |
| UniProt Related Accession: | Q9HDB5,Q9Y4C0 |
| Molecular Weight: | 69kDa |
| NCBI Full Name: | Neurexin-3-beta |
| NCBI Synonym Full Names: | neurexin 3 |
| NCBI Official Symbol: | NRXN3Â Â |
| NCBI Official Synonym Symbols: | C14orf60Â Â |
| NCBI Protein Information: | neurexin 3 |
| UniProt Protein Name: | Neurexin-3-beta |
| UniProt Synonym Protein Names: | Neurexin III-beta |
| Protein Family: | Neurexin |
| UniProt Gene Name: | NRXN3Â Â |
| Antibodies |
| NRXN3 Antibody (PACO05751) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
NRXN3 Antibody (PACO05751)
NRXN3 Antibody (PACO45332)
NRXN3 Rabbit Polyclonal Antibody (CAB10269)
Human NRXN3 (Neurexin-3) ELISA Kit (HUFI03414)
Human Neurexin-3 beta/NRXN3 PharmaGenie ELISA Kit (SBRS0945)
