NRXN3 Antibody (PACO05751)
- SKU:
- PACO05751
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NRXN3 Antibody (PACO05751)
The NRXN3 Polyclonal Antibody (PACO05751) is a valuable tool for researchers studying the neurexin 3 protein, an important cell adhesion molecule involved in synaptic function and neurological disorders. This antibody, produced in rabbits, demonstrates high reactivity with human tissue samples and is specifically validated for use in Western blot applications. By targeting the NRXN3 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in neuroscience and brain-related diseases.
Neurexin 3 is crucial for synaptic connectivity and communication in the brain, playing a key role in regulating neurotransmission and neuronal signaling. Dysregulation of NRXN3 has been implicated in various neurological disorders, including autism spectrum disorders, schizophrenia, and intellectual disabilities. By studying the function and expression of NRXN3 using this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
| Antibody Name: | NRXN3 Antibody (PACO05751) |
| Antibody SKU: | PACO05751 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human Neurexin III β . |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | NRXN3; KIAA0743; Neurexin-3-β; Neurexin III-β |
| UniProt Protein Function: | NRXN3B: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. {ECO:0000250}. Belongs to the neurexin family. {ECO:0000305}. The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3. Weakly interacts with CBLN1 and CBLN2. Very weak binding, if any, with CBLN4. {ECO:0000250}. 7 isoforms of the human protein are produced by alternative promoter |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q24.3-q31.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:cell adhesion molecule binding; receptor activity Biological Process: adult behavior; axon guidance; learning; neuron adhesion; social behavior |
| NCBI Summary: | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9HDB5 |
| NCBI GenInfo Identifier: | 218512141 |
| NCBI Gene ID: | 9369 |
| NCBI Accession: | Q9HDB5.4 |
| UniProt Secondary Accession: | Q9HDB5,Q6NUR0, Q8IUD8, A5PKW8, A8MPU5, B3KPM7, |
| UniProt Related Accession: | Q9HDB5,Q9Y4C0 |
| Molecular Weight: | 69kDa |
| NCBI Full Name: | Neurexin-3-beta |
| NCBI Synonym Full Names: | neurexin 3 |
| NCBI Official Symbol: | NRXN3Â Â |
| NCBI Official Synonym Symbols: | C14orf60Â Â |
| NCBI Protein Information: | neurexin 3 |
| UniProt Protein Name: | Neurexin-3-beta |
| UniProt Synonym Protein Names: | Neurexin III-beta |
| Protein Family: | Neurexin |
| UniProt Gene Name: | NRXN3Â Â |
Related Products
NRXN3 Antibody (PACO41366)
NRXN3 Antibody (PACO45332)
NRXN3 Rabbit Polyclonal Antibody (CAB10269)
Human NRXN3 (Neurexin-3) ELISA Kit (HUFI03414)
Human Neurexin-3 beta/NRXN3 PharmaGenie ELISA Kit (SBRS0945)
