The NRXN1 Polyclonal Antibody (PAC045462) is a valuable tool for researchers studying neurexin 1 (NRXN1), a cell adhesion molecule involved in synaptic function and neurodevelopmental disorders. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot and immunohistochemistry applications. By binding specifically to NRXN1, researchers can accurately detect and analyze this protein in various cell types and tissues, making it an ideal choice for studies in neuroscience and neurology.NRXN1 is a key player in synaptic transmission and connectivity in the brain, making it essential for proper brain function and development.
Dysregulation of NRXN1 has been linked to various neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia. Studying the role of NRXN1 in these conditions is crucial for advancing our understanding of neurological diseases and developing targeted therapies to improve patient outcomes.Overall, the NRXN1 Polyclonal Antibody (PAC045462) provides researchers with a reliable tool to investigate the function and dysregulation of NRXN1 in both health and disease, paving the way for new insights and potential therapeutic interventions in neuroscience research.
Antibody Name:
NRXN1 Antibody (PACO45462)
Antibody SKU:
PACO45462
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Neurexin-1 protein (31-310AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human brain tissue using PACO45462 at dilution of 1:100.
Background:
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.
NCBI Summary:
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
