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NRXN1 Antibody (PACO45461)

SKU:
PACO45461
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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NRXN1 Antibody (PACO45461)

The NRXN1 Polyclonal Antibody (PACO45461) is a valuable tool for research involving NRXN1, a neuronal cell surface receptor known for its role in synapse formation and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blot and immunohistochemistry.NRXN1, a member of the neurexin family, is essential for proper communication between neurons in the brain and is implicated in various neurological disorders, including autism spectrum disorders and schizophrenia. By targeting the NRXN1 protein, researchers can investigate its function in synaptic transmission and synaptic plasticity, providing insights into the pathophysiology of neurodevelopmental and psychiatric disorders.

With its ability to specifically bind to NRXN1, this antibody enables the detection and analysis of the protein in different cell types and tissues, making it a valuable tool for studies in neuroscience and neurology. By elucidating the role of NRXN1 in synaptic connectivity, researchers can pave the way for the development of novel therapeutic interventions for neurological conditions associated with synaptic dysfunction.

Antibody Name:NRXN1 Antibody (PACO45461)
Antibody SKU:PACO45461
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:Human
Immunogen:Recombinant Human Neurexin-1 protein (31-310AA)
Form:Liquid
Storage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: NRXN1 antibody at 1.57µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 162, 165, 170, 47, 16, 51 kDa. Observed band size: 162 kDa..
Background:Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
Synonyms:Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha), NRXN1, KIAA0578
UniProt Protein Function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.
NCBI Summary:This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
UniProt Code:Q9ULB1
NCBI GenInfo Identifier:1052292378
NCBI Gene ID:9378
NCBI Accession:NP_001317021.1
UniProt Secondary Accession:Q9ULB1,E7ETA5,
UniProt Related Accession:P58400,Q9ULB1
Molecular Weight:161,883 Da
NCBI Full Name:neurexin-1 isoform beta3
NCBI Synonym Full Names:neurexin 1
NCBI Official Symbol:NRXN1  
NCBI Official Synonym Symbols:PTHSL2; SCZD17; Hs.22998  
NCBI Protein Information:neurexin-1
UniProt Protein Name:Neurexin-1-beta
UniProt Synonym Protein Names:Neurexin I-beta
Protein Family:Neurexin
UniProt Gene Name:NRXN1  
AntibodiesELISA Kits
NRXN1 Antibody (PACO05753)Human NRXN1 (Neurexin-1) ELISA Kit (HUFI03413)
NRXN1 Antibody (PACO10937)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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