The NRXN1 Antibody (PAC010937) is a polyclonal antibody designed for research involving NRXN1, a cell adhesion molecule that plays a crucial role in synaptic function and neuronal communication. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blotting.NRXN1 is known to be involved in neurodevelopmental disorders such as autism spectrum disorders and schizophrenia, making it a key target for studies in neuroscience and psychiatric research.
By detecting and analyzing the NRXN1 protein, researchers can gain insights into its function and potential implications in neurological conditions.Understanding the role of NRXN1 in synaptic communication and neuronal development is essential for advancing our knowledge of brain function and potentially identifying new therapeutic targets for neurological disorders. The NRXN1 Antibody provides a valuable tool for investigating the biology of NRXN1 and its impact on neurological health.
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.
NCBI Summary:
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
