Neuropilin-1 (NRP1) Rabbit Polyclonal Antibody (CAB16697)
- SKU:
- CAB16697
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Product Name: | Neuropilin-1 (NRP1) Rabbit Polyclonal Antibody |
| SKU: | CAB16697 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Neuropilin-1 (NRP1) (NP_003864.5). |
| Sequence: | FELV DGVK LKKD KLNT QSTY SEA |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
| Synonyms: | NP1; NRP; BDCA4; CD304; VEGF165R; Neuropilin-1 (NRP1) |
| Positive Sample: | PC-3,Mouse lung,Rat lung |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
| Calculated MW: | 103kDa |
| Observed MW: | 120kDa |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.
| Purification Method: | Affinity purification |
| Gene ID: | 8829 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Western blot analysis of extracts of various cell lines, using Neuropilin-1 (NRP1) antibody (CAB16697) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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