NRN1 Antibody (PACO40846)
- SKU:
- PACO40846
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NRN1 Antibody (PACO40846)
The NRN1 Polyclonal Antibody (PAC040846) is a vital tool for researchers studying NRN1, a brain-specific protein involved in synaptic plasticity and neuronal development. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting NRN1 in various experimental applications, particularly in Western blotting. By targeting the NRN1 protein, this antibody allows for the precise identification and analysis of NRN1 expression in different cell types, making it an excellent choice for studies in neurobiology and neurodevelopment.
NRN1, also known as neuritin, plays a crucial role in promoting neurite outgrowth and synaptic connectivity in the nervous system. Its involvement in neuroplasticity processes suggests its potential as a therapeutic target for neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. Investigating the functions of NRN1 with the help of this antibody provides valuable insights into the mechanisms underlying brain development and function, paving the way for the development of novel treatments for neurodegenerative conditions.
| Antibody Name: | NRN1 Antibody (PACO40846) |
| Antibody SKU: | PACO40846 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Neuritin protein (28-116AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO40846 at dilution of 1:100. |
| Background: | Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. |
| Synonyms: | Neuritin, NRN1, NRN |
| UniProt Protein Function: | NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6p25.1 Cellular Component: plasma membrane; synapse; cell junction Biological Process: nervous system development |
| NCBI Summary: | This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9NPD7 |
| NCBI GenInfo Identifier: | 74752881 |
| NCBI Gene ID: | 51299 |
| NCBI Accession: | Q9NPD7.1 |
| UniProt Secondary Accession: | Q9NPD7,Q7Z4Y1, B2RA93, |
| UniProt Related Accession: | Q9NPD7 |
| Molecular Weight: | 15,333 Da |
| NCBI Full Name: | Neuritin |
| NCBI Synonym Full Names: | neuritin 1 |
| NCBI Official Symbol: | NRN1Â Â |
| NCBI Official Synonym Symbols: | NRN; dJ380B8.2Â Â |
| NCBI Protein Information: | neuritin |
| UniProt Protein Name: | Neuritin |
| Protein Family: | Neuritin |
| UniProt Gene Name: | NRN1Â Â |
| UniProt Entry Name: | NRN1_HUMAN |
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