Anti-NRN1 Antibody (PACO14755)

Antibody Name:	NRN1 Antibody (PACO14755)
Antibody SKU:	PACO14755
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human NRN1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14755(NRN1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14755(NRN1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants.

Synonyms:

neuritin 1

UniProt Protein Function:	NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family.
UniProt Protein Details:	Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6p25.1 Cellular Component: plasma membrane; synapse; cell junction Biological Process: nervous system development
NCBI Summary:	This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:	Q9NPD7
NCBI GenInfo Identifier:	74752881
NCBI Gene ID:	51299
NCBI Accession:	Q9NPD7.1
UniProt Secondary Accession:	Q9NPD7,Q7Z4Y1, B2RA93,
UniProt Related Accession:	Q9NPD7
Molecular Weight:	15,333 Da
NCBI Full Name:	Neuritin
NCBI Synonym Full Names:	neuritin 1
NCBI Official Symbol:	NRN1
NCBI Official Synonym Symbols:	NRN; dJ380B8.2
NCBI Protein Information:	neuritin
UniProt Protein Name:	Neuritin
Protein Family:	Neuritin
UniProt Gene Name:	NRN1
UniProt Entry Name:	NRN1_HUMAN

ELISA Kits

Human Neuritin ELISA Kit

Human Neuritin (NRN1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)