NRN1 Antibody (PACO14755)
- SKU:
- PACO14755
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
NRN1 Antibody (PACO14755)
The NRN1 Polyclonal Antibody (PAC014755) is a valuable tool for researchers investigating NRN1, a neurotrophic factor involved in the growth and differentiation of neurons. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the NRN1 protein, this antibody enables the detection and analysis of NRN1 in various cell types, making it well-suited for studies in neuroscience and neurodegenerative diseases.NRN1, also known as neuritin, is a critical player in neuronal development and plasticity, promoting the survival, growth, and function of neurons.
Its role in regulating synaptic plasticity and neuronal connectivity makes it a promising target for research on conditions like Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Understanding the functions of NRN1 is essential for developing therapeutic interventions that enhance neuronal repair and regeneration in these disease contexts.
| Antibody Name: | NRN1 Antibody (PACO14755) |
| Antibody SKU: | PACO14755 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human NRN1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14755(NRN1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14755(NRN1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. |
| Synonyms: | neuritin 1 |
| UniProt Protein Function: | NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6p25.1 Cellular Component: plasma membrane; synapse; cell junction Biological Process: nervous system development |
| NCBI Summary: | This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9NPD7 |
| NCBI GenInfo Identifier: | 74752881 |
| NCBI Gene ID: | 51299 |
| NCBI Accession: | Q9NPD7.1 |
| UniProt Secondary Accession: | Q9NPD7,Q7Z4Y1, B2RA93, |
| UniProt Related Accession: | Q9NPD7 |
| Molecular Weight: | 15,333 Da |
| NCBI Full Name: | Neuritin |
| NCBI Synonym Full Names: | neuritin 1 |
| NCBI Official Symbol: | NRN1Â Â |
| NCBI Official Synonym Symbols: | NRN; dJ380B8.2Â Â |
| NCBI Protein Information: | neuritin |
| UniProt Protein Name: | Neuritin |
| Protein Family: | Neuritin |
| UniProt Gene Name: | NRN1Â Â |
| UniProt Entry Name: | NRN1_HUMAN |
Related Products
NRN1 Antibody (PACO40846)
NRN1 Antibody (PACO14756)
