The NRG4 Polyclonal Antibody (CAB2599) is specifically designed for research involving NRG4, a member of the epidermal growth factor (EGF) family that plays a crucial role in metabolic regulation and energy homeostasis. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.NRG4 is a biomarker associated with metabolic disorders, such as obesity and diabetes, as well as various cancers. Studies have shown that NRG4 is involved in regulating lipid metabolism, glucose homeostasis, and insulin sensitivity.
The NRG4 Polyclonal Antibody binds specifically to NRG4 protein, allowing for accurate detection and analysis in different cell types.The role of NRG4 in metabolic health and disease makes it a key target for research aimed at understanding the molecular mechanisms underlying metabolic disorders and exploring potential therapeutic interventions. By studying the expression and function of NRG4, researchers can gain insights into the development of new treatments for metabolic diseases and cancer.
Product Name:
NRG4 Rabbit Polyclonal Antibody
SKU:
CAB2599
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
13kDa
Observed MW:
13kDa
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
Purification Method:
Affinity purification
Gene ID:
145957
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using NRG4 Rabbit pAb (CAB2599) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
