The NRF2 Monoclonal Antibody (CAB21176) is a valuable tool for researchers studying NRF2, a transcription factor known for its role in cellular response to oxidative stress. The antibody, generated in mice, is specifically designed for use in immunohistochemistry and immunofluorescence applications, providing high specificity and sensitivity for detecting NRF2 expression in various tissue samples.NRF2 is a master regulator of antioxidant response genes, playing a key role in protecting cells from oxidative damage and promoting cell survival under stress conditions. Dysregulation of NRF2 signaling has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
As such, studying NRF2 expression and activity is crucial for understanding the pathogenesis of these diseases and developing targeted therapies.The NRF2 Monoclonal Antibody (CAB21176) offers researchers a reliable tool for investigating NRF2 function and regulation in different biological contexts. Its high specificity and sensitivity make it an essential resource for studies aiming to elucidate the role of NRF2 in health and disease, paving the way for the development of novel therapeutic approaches targeting NRF2 signaling pathways.
Product Name:
NRF2 Monoclonal Antibody
SKU:
CAB21176
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 243-400 of human NRF2 (NP_006155.2).
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene.
Purification Method:
Affinity purification
Gene ID:
4780
Clone Number:
ARC50393
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using NRF2 Rabbit mAb (CAB21176) at1:1000 dilution.NIH/3T3 cells were treated by MG132(50 μM) at 37℃ for 90 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
